Discovery

The tiny sap-sucking aphid, at just a few millimetres long, is the scourge of many gardeners and crop-growers worldwide, spreading astonishingly rapidly and inflicting huge damage as it seeks to outwit many host plants’ natural defences. With insights and guidance from aphid expert George Seddon-Roberts at the John Innes Centre, Norwich, some delicate dissecting tools, and a state of the art microscope, Professor Ben Garrod and Dr Jess French delve inside this herbivorous insect to unravel the anatomy and physiology that’s secured its extraordinary reproductive success, whilst offering new clues as to how we could curtail its damaging impact in the future.

Co-Presenters: Ben Garrod and Jess French Executive Producer: Adrian Washbourne Producer: Ella Hubber Editor: Martin Smith Production Co-ordinator: Jana Bennett-Holesworth

2000 years ago Lucretius composed a long poem that theorised about atoms and the natural world. Written in the first century BCE, during a chaotic and frightening time when the Roman Republic was collapsing, Lucretius encouraged people to feel free through contemplating the physics of the Universe. He said that despite living through a time of bloody civil wars and dictatorship people should not believe they were sheep who had to follow those in power.

Naomi discovers that the poem is an epic, beautiful and persuasive piece of work. It begins with a discussion of atoms. Lucretius, like Epicurus, followed the Greek tradition in believing that the universe is composed of tiny, indivisible particles. De Rerum Natura asks us to consider that all that really exists in the universe are these atoms and the void between them. Atoms are indestructible, the number of atoms in the universe is infinite and so is the void in which the atoms move. What Lucretius is saying here was revolutionary then – and still has the power to surprise. He’s saying that there are no supernatural forces controlling our lives, no fate pulling the strings, if there are gods they’re made of atoms just like everything else. There is nothing else. Naomi discusses the life of Lucretius and his poem with classicist Dr Emma Woolerton of Durham University. And she talks to particle physicist Professor Jonathan Butterworth of UCL about which of his theories still holds water today.

Picture: Gathered sheep, Credit: Chris Strickland, Getty Images

Philip Ball's tale is of a solar eclipse 100 years ago observed by Arthur Eddington, a British astronomer who travelled to the remote island of Principe off the coast of West Africa and saw the stars shift in the heavens. His observations supplied the crucial proof of a theory that transformed our notions of the cosmos and turned a German physicist named Albert Einstein into an international celebrity. But this is also a tale of how a Quaker tried to use science to unite countries. The reparations imposed on Germany after the war extended into science too as many in Great Britain and other Allied nations felt that German science should be ostracised from the international community. As a Quaker, Eddington wanted just the opposite: to see peaceful cooperation restored among nations.

Picture: Image of the 1919 Solar eclipse taken by Arthur Eddington (1882-1944), Credit: Science Photo Library

Producer: Erika Wright

On Christmas Eve in 1968 Bill Anders was in orbit around the moon in Apollo 8 when he took one of the most iconic photos of the last fifty years: Earthrise. The image got to be seen everywhere, from a stamp issued in 1969 to commemorate the success of Apollo 8, to posters that are still available today. Gaia Vince explores the impact of this image on the environmental movement and our understanding of our place in the universe.

“Oh my God. Look at that picture over there. Here’s the earth coming up. Wow, isn’t that pretty.”

Bill Anders was on the fourth of the ten orbits of the moon on Apollo 8, along with James Lovell and Frank Borman. Bill had spotted the earth through one of the hatch windows and grabbed his camera to take a black and white photo. But just in time, he picked up another camera with a colour film loaded, and the rest is history. When they returned from space – the first mission to orbit the moon – Nasa used Bill Anders’ image of Earthrise in its publicity. Nasa had understood there was an added value of going into space: taking pictures of our home planet.

Stewart Brand was part of both the counterculture and the environmental movement; he’d hung out with Ken Kesey and his merry pranksters and put on happenings. He went on to found the Whole Earth Catalog, which brought together all kinds of alternative thinkers. Stewart Brand put the Earthrise photo on the front cover of one of the editions of the Whole Earth Catalog.

Gaia Vince talks to Stewart Brand, and to scientists and artists, about the continuing importance of seeing Earth from above.

Picture: Earthrise - The rising Earth is about five degrees above the lunar horizon in this telephoto view taken from the Apollo 8 spacecraft on December 24th 1968, Credit: Nasa

Presenter: Gaia Vince Producer: Deborah Cohen

Alex Bellos is brilliant at all things mathematical, but even he can't hold a candle to the amazing mathematical feats of the supercalculators. Alex heads to Wolfsburg in Germany to meet the contestants at this year's Mental Calculation World Cup. These men and women are the fastest human number crunchers on the planet, able to multiply and divide large numbers with no need to reach for a smart phone, computer or calculator. So how do they do it, and is it a skill that any of us can learn? Alex talks to Robert Fountain, the UK's two-time winner of this prestigious prize, about his hopes for this year's competition and the mathematical magicians of the past who have inspired him. He also meets Rachel Riley, Countdown's number queen, to find out what it takes to beat the countdown clock.

Picture: The Supercalculators, Credit: Alex Bellos

Plastic waste and pollution have become a global problem but is there any sign of a global solution? And how did we allow this to happen in the first place? Materials scientist and broadcaster, Professor Mark Miodownik, explores how we fell in love with plastic, why we've ended up with oceans of waste blighting the environment and what science and society can do about it.

Programme Three: Roland Pease hears from Kenya where one of the most stringent bans on plastic bags has been in force for nearly two years, from the US where the reuseable cup has taken off and from Sweden where reverse vending machines give you money back when you return your plastic bottles. And he looks at places where plastic is the best material for the job.

Picture: Bike loaded with empty plastic bottles. Shanghai China, Credit: typhoonski/Getty Images

Plastics are fantastically versatile materials that have changed our lives. It is what we do with them, when we no longer want them, that has resulted in the global plastic crisis. Mark Miodownik explores our love hate relationship with plastics. Programme Two: Things begin to go stale Plastic waste has been a global crisis waiting to happen. To date it's estimated that around 8.3 billion tonnes of waste plastic exists. That's 25 Empire State Buildings or 1 billion elephants. Incredibly around half of this has been generated in just the last 14 years, despite mass production having begun in the 1950s. Events such as China's recent refusal to take any more "foreign rubbish" from the west and Sir David Attenborough's graphic portrayal of the devastation that plastic waste is causing in our oceans, has prompted political and media discussion like never before. We are at a critical moment where, if we're to turn the tide on plastic pollution, it will require science and society to come together to create real change. But it won't be easy. One major area that needs an overhaul is recycling. In the UK only 14% of plastic collected is recycled. Europe tends to burn our waste for energy, and plastic has a calorific value similar to that of coal. But proponents of the circular economy say we should never consider plastic as waste at all and we should think of it as 'Buried Sunshine' - a resource that needs conserving - by reusing and recycling again and again.

Picture: Production line for the processing of plastic waste in the factory, Credit: Getty Images

Plastic waste and pollution have become a global problem but is there any sign of a global solution? And how did we allow this to happen in the first place? Materials scientist and broadcaster, Professor Mark Miodownik, explores how we fell in love with plastic, why we've ended up with oceans of waste blighting the environment and what science and society can do about it. Programme One: First Flush of Love We may not be on speaking terms right now. But we do have a love affair with plastic, in fact it can be all consuming. Adaptable, lightweight, cheap and hygienic - fantastic plastics started to win our affection back in the late 19th century. Bakelite was an early plastic invented to replace expensive wood. Celluloid was one of the earliest plastics, failing to replace ivory in billiard balls, but revolutionising the world as movie film. Plastic really did change our world. Plastic radar insulation played a role in helping the Allied forces win the Second World War and after the conflict, factories start to churn out cheap, mass-produced goods in the new synthetic polymers. But some of the key virtues of plastic may now have paradoxically poisoned the relationship. Being virtually indestructible, has led to a build-up of toxic micro-plastic in the oceans and environment. We've grown to regard many plastics as cheap and disposable, we take it for granted, rely on it too much, value it too little and are too ready to cast it aside after one single use.

Producer: Fiona Roberts

Picture: The Bakelite Museum, Credit: Getty Images

The first Coelacanth was discovered by a woman in South Africa in 1938. The find, by the young museum curator, was the fish equivalent of discovering a T- Rex on the Serengeti, it took the Zoological world by storm. Presenter Adam Hart tells the story of this discovery, and the steps taken by Coelacanth biologists in the decades since to find more fish, in other populations, and record them for science. Adam hears personal accounts from a deep diver who swam with Coelacanths, Eve Marshall, conservationist Dr Mark Erdman, and geneticist Professor Axel Meyer.

Picture: 3 Coelacanths at 116 metres depth in Sodwana Bay, South Africa, Credit: Eve Marshall

Producer: Rory Galloway

Evidence for the big bang was initially thought to be a mistake in the recording. Jet streams in the upper atmosphere were revealed by the dust emitted by Krakatoa and a collection of interested citizen scientists. In the second three episodes about the genius of accidents in science, presenter Adam Hart explores two stories of unexpected observations. Sometimes accidental discoveries are bigger than you might expect.

Picture: Moonlit Coast, Credit: shaunl/Getty Images

Viagra’s effects on men were first discovered as an unexpected side-effect during trials for a medication meant to help patients with a heart condition. CRISPR cas– 9 is now a tool that can be used to modify and replace genes – but it was first noted as a random collection of genes. In the first of three episodes about the genius of accidents in science, Professor Adam Hart explores how, sometimes, the results you’re looking for are not as important as those that appear unexpectedly.

Picture: Test Tubes, Credit: Grafner/Getty Images

Producer: Rory Galloway

What were the earliest animals on Earth? The origin of the animal kingdom is one of the most mysterious chapters in the evolution of life on Earth. Our animal ancestors appeared and began to diversify about half a billion years ago. What might they have looked like, and which creatures alive today can be traced to these primordial times? Answers are beginning to come with new techniques for both studying ancient fossils and for reading evolutionary history from the DNA of animals alive today. Zoologist Professor Matthew Cobb explores the latest discoveries and controversies with the researchers on the trail of the Earth’s first animals.

Producer: Andrew Luck-Baker

Picture: Artists impression of Dickinsonia, Credit: Nasa

Mary Anning lived in Lyme Regis on what is now known as the Jurassic Coast in the first half of the 19th century. Knowing the shore from childhood and with a remarkable eye for detection she was extremely successful in finding fossils. In 1812 she unearthed parts of an Icthyosaur and in 1823 she discovered the first skeleton of what became known as a Plesiosaurus – a long-necked, flippered creature with a tiny head. It looked a bit like an elongated turtle with no shell. Naomi Alderman tells the science story of how Mary Anning, a poor and relatively uneducated young woman, became the supplier of the best fossils to the gentlemen geologists who were beginning to understand that the earth was very old and had been inhabited by strange extinct creatures. Naomi talks to Tracy Chevalier, author of Remarkable Creatures, a novel about Mary Anning, about her life and relationship with the geologists of the time, and to Dr Susannah Maidment, Curator of Dinosaurs at the Natural History Museum, about fossil hunting today.

Image: Lyme Regis, from Charmouth, Dorset 1814-1825 by William Daniell (Credit: Historica Graphica Collection/Heritage Images/Getty Images)

The summer of 2003 saw the largest number of deaths ever recorded in a UK heatwave - but by 2040 climate models predict the extreme summer temperatures experienced then will be normal. We will also be experiencing colder winters, and droughts and floods will become more common.

Our infrastructure, housing, water, sewerage, transport and public buildings are not designed for such conditions. Gaia Vince asks how we can adapt and prepare our cities, where most people live and work, for the new normal weather conditions.

New buildings in temperate climates are now designed with keeping us warm in mind, better insulation, more efficient heating and airtight glazing. However when it comes to overheating these measures designed to keep out the cold can be part of the problem.

Can we adapt solutions from other countries where extreme heat is a more usual seasonal event?

Will we simply have to change the way we organise our day to keep out of the heat? Is the real answer for mad dogs and Englishmen to take a siesta?

Picture: Wood thermometer, Credit: Ugurhan/Getty Images

In the second programme exploring the Chinese approach to organ transplantation, Matthew Hill looks at what is happening today. Where are the organs coming from today? Have the Chinese overcome their traditional opposition to donating them? There is still a lack of transparency about the sources. Some critics have suggested that there is still a trade in organs and there are reports that transplant tourism is still going on. Matthew Hill talks to Chinese and international transplant doctors about the current situation.

Picture: Asian surgeons in the operating room, Shanghai, China, Credit: Asia-Pacific Images Studio/Getty Images

For many years the Chinese sourced organs for transplant from executed prisoners. Around a decade ago the authorities acknowledged that this practice had gone on and announced that it was to be stopped. In the first programme exploring the Chinese approach to organ transplantation Matthew Hill tells the grim story of the revelation of the source of organs, he meets a surgeon with first-hand experience of removing organs from executed prisoners. We talk to campaigners who believe the practice is still going on, they allege religious and ethnic minority groups in China are now a source for an illicit trade in human organs. Officially the practice of using organs for transplant from executed Prisoners ceased in 2015, China now has an organ donation registry and say the majority of organs come from people who die in intensive care units, however questions remain over whether this source is sufficient for the number of transplants performed.

Picture: Asian surgeons in the operating room, Shanghai, China, Credit: Asia-Pacific Images Studio/Getty Images

This summer the Northern Hemisphere has been sweltering in unusually high temperatures. It has been hot from the Arctic to Africa. This has led to increased deaths, notably in Canada, and more wildfires, even in Lancashire and in Sweden. Can we say that this heatwave – and the extreme drought in Australia - is a result of climate change? Or is just part of the variable weather patterns we have on our planet? Roland Pease gets answers to these questions from the world’s leading climate and weather scientists. He picks apart the influences of the jet stream, El Niño and the Atlantic decadal oscillation from that of global warming.

(Photo: Arctic Pack Ice near Svalbard, Norway. Credit: Bkamprath/Getty Images)

This summer the Northern Hemisphere has been sweltering in unusually high temperatures. It’s been hot from the Arctic to Africa. This has led to increased deaths, notably in Canada, and more wildfires, even in Lancashire and in Sweden. Can we say that this heatwave – and the extreme drought in Australia – is a result of climate change? Or is just part of the variable weather patterns we have on our planet? Roland Pease gets answers to these questions from the world’s leading climate and weather scientists. He picks apart the influences of the jet stream, the El Nina and the Atlantic decadal oscillation from that of global warming.

Picture: Sacramento River and valley lit by the Delta Fire in California, 2018, Credit: Josh Edelson/AFP/Getty Images

Sophie Scott on why sodium powers everything we do, and why it might be the key to a new generation of pain killers.

Putting sodium into water is one of the most memorable experiments from school chemistry lessons. It's this ability to react ferociously with water which is the starting point for sodium's key role in powering all of biology. Simply, without sodium we wouldn't exist. It helps provide the electricity that allows us to move, breathe, think.

Our understanding of sodium could help in the search for analgesics with few side effects for severe pain. Recent discoveries of families who feel searing pain with mild warmth, or those who feel no pain at all even in childbirth, have opened up new avenues in pain research. Their rare genetic mutations change the way sodium works in their bodies: from this new knowledge neuroscientists are developing drugs that could give rise to a much needed new generation of pain killers.

Image: Traditional glass salt cellar (Credit: Getty Images)

Beyond war and peace, Dr Andrew Pontzen explores how iron has shaped human biology and culture.

From weapons to ploughshares, iron holds a key place as the element for the tools of the rise and destruction of human civilisations. As a grand scale shaper of our towns and ciities and our culture it is unmatched. And yet it also has a major role to play in living cells. Andrew Pontzen, Reader in Cosmology at University College London. explores iron's sometimes ambivalent history and also delves deep inside ourselves to understand how iron is key to keeping us all alive. Dr Kate Maguire, astrophysicist at Queens University, Belfast, explains how the iron on earth was formed in distant exploding stars. Andrew talks to Professor Marcos Martinón-Torres about how our ancestors first used this metal. And Dr Caroline Shenton-Taylor, of the University of Surrey, discusses one of iron’s greatest and most mysterious properties – magnetism. In blood and bodies what does iron actually do - could any other element perform its life giving functions? Andrew finds out from Chris Cooper, Emeritus Professor of Biochemistry at Essex University, how iron is the key atom in haemoglobin that transports oxygen. And Dr Kathryn Robson, from Oxford University’s Weatherall Institute of Molecular Medicine, describes the condition haemochromatosis,, in which people have too much iron. which runs in Andrew's family.

Picture: Rusty screws, Credit: Getty Images/hudiemm

Chemist Andrea Sella tells the story of how the feared element ended up giving us better teeth, mood and health.

Many chemists have lost their lives trying to isolate the periodic table’s most chemically reactive element – hence the nickname “the tiger of chemistry”. Fluorine can react with almost all elements. As an acid, hydrofluoric acid, it will dissolve glass. Yet chemists have been able to tame the beast – creating remarkable and safe uses for it by utilising its reactive nature that lets it make strong bonds with other chemicals. One in five medicines contain fluorine atoms, including one of the most widely used antidepressants Prozac, fluorinated anaesthetic, cancer medication, the cholesterol regulating drug Lipitor and the antibacterial Cipro. Though perhaps it is most famous for being added to toothpaste in the form of fluoride and in some places, drinking water. Fluoride protects our teeth from decay. But despite the benefits, it has a history of receiving a bad press. During the cold war, false allegations were made that adding fluoride to the water supply was a communist plot designed to weaken the American people. Stanley Kubrick satirised these fears in the film Dr. Strangelove in 1964. The suspicion around fluoride has not gone away and many people feel negatively towards any tinkering with something as fundamental as our water supply. Professor Andrea Sella from University College London examines the effects of fluorine and looks to current and future uses of the element that chemists clearly respect – but no longer fear.

Picture: Toothpaste, Credit: artisteer/Getty Images

Naomi Alderman's tale is a murder mystery, the story of Hypatia, the mathematician murdered by a mob in the learned city of Alexandria, around the year 415 CE. Hypatia was a communicator of science, tackling difficult maths and teaching it to her students. This was incredibly important work. It was enough, at the time, to make her Alexandria’s pre-eminent mathematician, and probably therefore the leading mathematician in the world. And there’s historical evidence that Hypatia made some discoveries and innovations of her own. She invented a new and more efficient method of long division. In a time before electronic calculators, the actual business of doing sums was an arduous part of engineering or astronomy, and any improvement in efficiency was very welcome. All quite innocent science, so why did Hypatia end up being murdered by a mob? Natalie Haynes tells the inside story to Naomi Alderman. And Professor Edith Hall discusses Hypatia's legacy.

Picture: Death of Hypatia of Alexandria (c 370 CE - March 415 AD), Credit: Nastasic/Getty Images

There's a story told about French philosopher René Descartes and his daughter. He boards a ship for a voyage over the North Sea with a large wooden box which he insists be handled with such great care that the sea captain’s curiosity is aroused. When Descartes is out of his cabin the sea captain opens the box and is horrified to find a life sized automaton inside. He's so shocked he throws the "daughter" overboard. Descartes championed a view of nature in which everything happened because of the physical forces acting between its constituent parts: nature as a machine. It was a coolly rational vision that caught the scientific spirit of the seventeenth century. He was fascinated by automata and what they tell us about what it is to be human. Philip Ball tells the story of Descartes and his "daughter" and his writings about humans and machines. He finds out more about the thirst for mechanical wonders and what it said about theories of the human body in Descartes’ time, from historian of science Simon Schaffer of Cambridge University. And Kanta Dihar of the Centre for the Future of Intelligence also at Cambridge University talks about current research into AIs, driven purely by some mechanism of formal logic, that can mimic the capabilities of the human mind, and how contemporary culture explores our fears about them.

Picture: People And Robots Modern Human And Artificial Intelligence Futuristic Mechanism Technology, Credit: Getty Images

Philip Ball tells the science story of German chemist Friedrich Wöhler’s creation of urea, an organic substance previously thought only to be produced by living creatures. Yet in 1828 Wöhler created urea from decidedly non-living substances. It was exciting because the accidental transformation seemed to cross a boundary: from inorganic to organic, from inert matter to a product of life. It’s a key moment in the history of chemistry but like many scientific advances, this one has also been turned into something of a myth. To read some accounts, this humble act of chemical synthesis sounds almost akin to the 'vital spark of being' described by Mary Shelley in her book published ten years previously, when Victor Frankenstein brought dead flesh back to life. Philip Ball sorts out fact from fiction in what Wohler really achieved in conversation with Peter Ramberg of Truman State University in Kirksville, Missouri, and finds out about chemical synthesis of natural products today from Professor Sarah O’Connor of the John Innes Centre.

Producer: Erika Wright

(Image: Friedrich Wohler, c 1850. Photogravure after a drawing by Hoffman, c 1850. From a collection of portraits of scientists published by Photographische Gesellschaft, Berlin, c 1910. Photo by SSPL/Getty Images)

Philip Ball reveals the real Cyrano de Bergerac - forget the big nosed fictional character - and his links to 17th Century space flight. Cyrano was a soldier, gambler and duellist who retired from military exploits on account of his wounds around 1639, at the grand old age of 20. But he studied at university and, to judge from the books he went on to write, he was well versed in the philosophical and scientific debates of his day. He designed spaceships to travel to the moon and to the sun. Philip discusses the life and times of Cyrano with Mary Baine Campbell of Brandeis University in Massachusetts.

Journeys to the New World in the seventeenth century were voyages of trade - and ultimately of colonisation. Today, the profit motive has returned to space travel. Efforts to develop spacecraft and to send people into space are increasingly being conducted not just by government agencies but by private companies, in search again of land and minerals. Philip discusses the control of exploitation of space with Patricia Lewis of ICAN, the International Campaign to Abolish Nuclear Weapons.

Producer: Erika Wright

Picture: To the moon by rocket-propelled box, 1640 as foreseen by Cyrano de Bergerac (1619-1655). Photo by: Universal History Archive / UIG via Getty Images)

A convent of Mexican nuns is helping to save the one of the world's most endangered and most remarkable amphibians: the axolotl, a truly bizarre creature of serious scientific interest worldwide and an animal of deep-rooted cultural significance in Mexico.

The Sisters of Immaculate Health rarely venture out of their monastery in the central Mexican town of Patzcuaro. Yet they have become the most adept and successful breeders of their local species of this aquatic salamander. Scientists marvel at their axolotl-breeding talents and are now working with them to save the animal from extinction. BBC News science correspondent Victoria Gill is allowed into the convent to discover at least some of the nun's secrets.

Producer: Andrew Luck-Baker

Picture: Lake Patzcuaro axolotl Credit: Credit the picture Will Condliffe, Chester Zoo

Victoria Gill tells the extraordinary story of the Mexican axolotl: an amphibian that is both a cultural icon and a biomedical marvel. In its domesticated form, the aquatic salamander is a valuable laboratory animal and a popular pet around the world. But in the wild, the species is on the very edge of extinction. Victoria visits one of its last hold-outs among the polluted canals in the south of Mexico City, where she meets the scientists and farmers working to save it.

Producer: Andrew Luck-Baker

Picture: Street Art, Credit: BBC

The microbiome is the strange invisible world of our non human selves. On and in all of us are hoards of microbes. Their impact on our physical health is becoming clear to science, but a controversial idea is emerging too - that gut bacteria could alter what happens in our brains.

In this final episode of the series BBC Science and Health correspondent James Gallagher examines a growing body of research into the gut as a gateway to the mind and why some scientists believe we could be o the cusp of a revolution in psychiatry that uses microbes to improve mental health.

Illustration by Katie Horwich

Producer: Adrian Washbourne

BBC Health and Science correspondent James Gallagher explores the latest research into how our second genome, the vast and diverse array of microbes that live on and in our bodies, is driving our metabolism and our health and how we can change it for the better.

In this second episode he explores how researchers are uncovering a vital relationship between the healthy bugs we accumulate in our gut and our immune system . We have over the past 50 years done a terrific job of eliminating infectious disease. But in we've also done the same to many good bacteria and as a result we're seeing an enormous and terrifying increase in autoimmune disease and in allergy. Could correcting our encounters with bugs at birth, and in the first few month of life set us on a path of good health? And in if in later life the delicate balance between our body and bugs gets skewed, leading to inflammatory diseases such as irritable bowel syndrome or frailty in old age, how can this be rectified?

Illustration by Katie Horwich

Producer: Adrian Washbourne

Are we on the cusp of a new approach to healthy living and treating disease? BBC Health and Science correspondent James Gallagher explores the latest research into how our second genome, the vast and diverse array of microbes that live on and in our bodies, is driving our metabolism and our health.

Recent DNA analysis by the Human Microbiome Project detailed the vast and diverse array of microbes in and on our body - bacteria, archaea, fungi and viruses. It has been described as our second genome - a source of huge genetic diversity, a modifier of disease, an essential component of immunity, and an "organ" that influences not just our metabolism but also our mental health. Unlike the human genome which is fixed at birth, this "second genome" can be manipulated in many ways.

Researchers have suggested that our gut microbiome has a major role in the development of chronic conditions such as obesity, inflammatory bowel disease and asthma. Now the work has moved onto detailed analysis of the microbes in people with specific problems and measures to change the microbiome.

In this major three-part series, James Gallagher investigates the key research shaping our ability not just to read our microbiome and look at predispositions, but to change it for the better. From the ability to manipulate it to stem chronic disease, to the role it plays in determining our health from birth, to its surprising influence on our brain and behaviour - should we now think of ourselves not as self-sufficient organisms, but as complex ecosystems colonized by numerous competing and health-giving microbes?

Picture: Probiotic bacteria Lactobacillus, Credit: Dr Microbe/Getty Images

Producer: Adrian Washbourne

Insects such as fruit flies provide important insights into human biology and medicine. But should we worry whether insects experience pain and suffering in scientists’ hands?

Entomologist Adam Hart visits the Fly Facility at the University of Manchester where researcher Andreas Prokop describes the many insights that experiments on the fruit fly Drosophila have provided on aspects of human biology and health. Globally billions of these little flies have died in the pursuit of this knowledge.

Should we give a second thought about the deaths of these creatures? Do insects have the capacity for pain and the experience of suffering? It depends which scientist you ask. Lars Chittka of Queen Mary University of London says his work on bumble bees suggests that we can’t assume they do not. Shelley Adamo of Dalhousie University in Canada is not convinced by existing arguments for insect consciousness.

Photo: Robber Fly Asilidae Diptera Insect, Credit: Nechaev-kon/Getty Images

Producer: Andrew Luck-Baker

Prof Adam Hart stirred a hornet’s nest of controversy by asking the public to kill wasps for science. He explores why scientists kill insects to save them from extinction.

The work of the entomologist often involves the killing of insects in large numbers. This happens in the search for new species in the exploration of the planet’s biodiversity and in ecological research to monitor the health of wild insect populations and the impact that we are having on the environment. But the methods of insects scientists have come under criticism.

Last year presenter and entomologist Adam Hart was involved in a citizen science project aimed at surveying the abundance of various species of British wasp around the country. The survey entailed members of the public setting up lethal wasp traps in their gardens and sending the dead insects to the lab running the survey. Many people took part but the study also generated negative newspaper coverage and stinging criticism on social media. How can you save insects by killing them?

Next week, do insects experience pain and suffering?

Picture: Broad-Bellied Chaser, Credit: BBC

Producer: Andrew Luck-Baker

Two small creatures are at the heart of today’s questions, sent in to curiouscases@bbc.co.uk.

The Tiniest Dinosaur "What is the tiniest dinosaur?" asks young listener Ellie Cook, aged 11.

Our hunt takes us from the discovery of dinosaurs right up to the present day, which is being hailed as a 'golden age' for palaeontology. Currently, one new species of dinosaur is unearthed on average every single week. But what's the smallest dino? And what can size reveal about the life of extinct animals? Hannah Fry goes underground at the Natural History Museum in London to look through their vaults in search of the tiniest dinosaur with palaeontologist Susie Maidment. Meanwhile Adam Rutherford chats to dinosaur expert Steve Brusatte from Edinburgh University about why size really does matter, especially when it comes to fossils.

The Baffled Bat "Why don't thousands of bats in a cave get confused? How do they differentiate their own location echoes from those of other bats?" This puzzling problem was sent in by Tim Beard from Hamburg in Germany. Since eco-location was first discovered, this question has perplexed biologists. Hannah turns bat detective to try and track down these elusive creatures at The Queen Elizabeth Olympic Park in East London. This is where zoologist Kate Jones from University College London is using a network of smart sensors to find, identify and track wild bats. Bat researcher and impressionist John Ratcliffe from Toronto University explains how bats use sonar to find their way around, and the clever tricks they’ve developed along the way. It's an unlikely tale involving gruesome early experiments, cunning electric fish and some surprising bat maths.

(Image: Dinosaurs and a meteor falling from the sky in back background. Credit: ugurhan/Getty Images)

Producer: Michelle Martin

Two astronomical questions today sent in to curiouscases@bbc.co.uk for Drs Hannah Fry and Adam Rutherford to answer.

The Cosmic Speed Limit "We often read that the fastest thing in the Universe is the speed of light. Why do we have this limitation and can anything possibly be faster?" asks Ali Alshareef from Qatif from Saudia Arabia. The team grapples with Einstein's Special Theory of Relativity, with help from cosmologist Andrew Pontzen and a British train, travelling somewhat slower than the speed of light. Plus physicist and presenter Jim Al-Khalili describes how he nearly lost his boxer shorts in a daring bet concerning the speed of subatomic particles.

The Cosmic Egg "How do we measure the age of the Universe?" asks Simon Whitehead. A hundred years ago this wouldn't even have been considered a valid question, because we didn't think the Universe had a beginning at all. Even Einstein thought that space was eternal and unchanging. This is the tale of how we discovered that the Universe had a beginning, and why calculating its age has been one of the greatest challenges in modern astronomy. We also uncover the mysterious dark energy that pervades the cosmos and discover why it's been putting a scientific spanner in the works. Helping to unravel today's question are physicists Andrew Pontzen, Jo Dunkley and Jim Al-Khalili.

Picture: Star sun supernova galaxy gold, Credit: Eastern Lightcraft/Getty Images

Producer: Michelle Martin

Adventures in Dreamland "Why do we dream and why do we repeat dreams?" asks Mila O'Dea, aged 9, from Panama.

Hannah Fry and Adam Rutherford delve into the science of sleep. From a pioneering experiment on rapid eye movement sleep, to a brand new 'dream signature' found in the brain, they discover how scientists are investigating our hidden dreamworld. Featuring sociologist Bill Domhoff from the University of California Santa Cruz, sleep psychologist Mark Blagrove from the University of Swansea, and neurologist Francesca Siclari from the University of Lausanne.

The Curious Face-Off "Are machines better than humans at identifying faces?" asks the excellently named Carl Vandal.

Today’s Face Off leads our intrepid detectives to investigate why we see Jesus on toast, Hitler in houses and Kate Middleton on a jelly bean. Face perception psychologist Rob Jenkins from the University of York explains why we're so good at spotting familiar faces, like celebrities. Plus, Franziska Knolle from the University of Cambridge discusses her face recognition study involving Barack Obama and a group of highly-trained sheep. But are we outwitted by artificial intelligence when it comes to face ID? BBC technology correspondent Rory Cellan-Jones gives us the low-down on the pros and cons of current technology.

Picture: Child sleeping, Credit: Quintanilla/Getty Images

Producer: Michelle Martin

Domestic science is on the agenda today, with two culinary questions sent in by listeners to curiouscases@bbc.co.uk

The Curious Cake-Off Can chemistry help us bake the perfect cake? Listener Helena McGinty aged 69 from Malaga in Spain asks, "'I have always used my mother's sponge cake recipe. But is there a noticeable difference in the outcome if you vary some of the ingredients, or the method?"

Hannah and Adam go head to head in a competition to create the perfect cake using the power of science. They are aided by materials scientist Mark Miodownik, from University College London, with tips on how to combine the ideal ingredients and trusted techniques to construct a structurally sound sponge. Food critic Jay Rayner is on hand to judge the results. But who will emerge victorious in this messy baking battle?

The Atomic Blade "What makes things sharp? Why are thinner knives sharper? What happens on the molecular level when you cut something?" All these questions came from Joshua Schwartz in New York City.

The ability to create sharp tools allowed us to fashion clothing, make shelters and hunt for food, all essential for the development of human civilisation. And, more importantly today they allow us to prepare dinner. So what makes kitchen knives sharp? We hear from IBM scientist Chris Lutz, who has used one of the sharpest blades in the world to slice up individual atoms. Plus palaeoarchaeologist Becky Wragg Sykes reveals the sharpest natural object in the world, a volcanic glass used by the Aztecs called ‘obsidian’.

Picture: Colourful Cupcakes, Credit: RuthBlack/Getty Images

Producer: Michelle Martin

Two very annoying cases today sent in by listeners to curiouscases@bbc.co.uk to our scientific sleuths, mathematician Dr Hannah Fry and geneticist Dr Adam Rutherford.

The Sticky Song Why do songs get stuck in our heads? And what makes some tunes stickier than others? Drs Rutherford and Fry investigate 'earworms', those musical refrains that infect our brains for days.

Every morning BBC 6Music DJ Shaun Keaveny asks his listeners for their earworms, and Hannah finds out which tunes keep coming back. Adam asks Dr Lauren Stewart, from Goldsmiths University, to reveal the musical features that make some songs catchier than others. And they find out why, in times of crisis, an earworm may just save your life.

The Shocking Surprise Jose Chavez Mendez from Guatemala asks, "Some years ago, in the dry season, I used to be very susceptible to static electricity. I want to know - why do static shocks happen?"

The team uncover some slightly unethical science experiments on static electricity from the 1700s. Hannah Fry uses a Leyden Jar to demonstrate how static electricity works with help from her glamorous assistant, Adam Rutherford. Spoiler Alert: it doesn't end well for Adam. They discover what makes some people more susceptible to static shocks, and how bees and spiders have harnessed the awesome power of electricity.

Featuring electromagnetism scientist Rhys Phillips and physicist Helen Czerski, author of 'Storm in a Teacup: The Physics of Everyday Life'.

Picture: Human Ear, Credit: Techin24/Getty Images

Producer: Michelle Martin

Humans have become the most successful species on earth because of our ability to cooperate. Often we help strangers when there is no obvious benefit to us as individuals. But today in the age when social media and the internet could be seen as a way of bringing people together more than ever, the opposite is happening. In this two-part series for Discovery science writer Gaia Vince meets the psychologists, evolutionary biologists and neuroscientists who are studying our built in human behaviour in groups and asks how their discoveries can guide projects to increase cooperation.

(Photo: Support button on keyboard, Credit: Abdoudz/Getty Images)

People are incredibly rude to each other on social media. Much ruder than they would ever be face to face. The great potential of the internet to bring humanity together in a glorious collaborating network seems naïve – instead of embracing a massive extension of our social circles, we seem to revert to tribalism and conflict online. And while we generally conduct our real-life interactions with strangers with politeness and respect, online, we can be horrible.

But it was our human ability to communicate ideas across networks of people that enabled us to so successfully solve life’s challenges and to build the modern world. Gaia Vince travels to Yale University to meet the researchers who are studying how we cooperate today and why it can go wrong when we communicate online.

Part of the Crossing Divides season.

(Photo: Row of children hugging Credit: Kieferpix/Getty Images)

Schrodinger's cat is the one that's famously alive and dead. At the same time. Impossible! Roland Pease meets the quantum scientists hoping to bring one to life in the laboratory. Not a real cat, to be fair. But large biomolecules, viruses, even bacteria, that can exhibit the quantum duality parodied in the paradox first described by one of the fathers of quantum physics. Because if they succeed, they may learn something about the interface between the quantum world, and the human world we live in.

Presenter/Producer: Roland Pease

Credit: Harald Ritsch/Science Photo Library

Barbara McClintock’s work on the genetics of corn won her a Nobel prize in 1983. Her research on jumping genes challenged the over-simplified picture of chromosomes and DNA that Watson and Crick’s discovery has all too often been used to support. During the half century that she worked at the Cold Spring Harbor Laboratory she became something of a living legend, a pioneer in a time when women weren’t expected to take much interest in science. In that story, she made a profound discovery that her male colleagues dismissed for years, leaving her out in the cold until they finally realized that it was true and granted her a belated Nobel Prize. Philip Ball tells the story of Barbara McLintock's life and work, from her early preference for sports, for solitude, and for intellectual life, that disturbed her parents, to her meticulous research on corn. In conversation with her recent biographer, Dr Nathaniel Comfort of Johns Hopkins University, he explores the facts and the fictions that grew up around her. Philip Ball talks about the legacy of her discovery of jumping genes with Professor Greg Hannon of the Cancer Research UK Institute at Cambridge University, who spent 25 years working in the McLintock Laboratory at Cold Spring Harbor.

Picture Corn Cobs, Credit: Philippe Huguen/AFP/GettyImages)

One hundred years ago D'Arcy Wentworth Thompson published On Growth and Form, a book with a mission to put maths into biology. He showed how the shapes, forms and growth processes we see in the living world aren’t some arbitrary result of evolution’s blind searching, but are dictated by mathematical rules. A flower, a honeycomb, a dragonfly’s wing: it’s not sheer chance that these look the way they do. But can these processes be explained by physics? D'Arcy Thompson loved nature’s shapes and influenced a whole new field of systems biology, architects, designers and artists, including Henry Moore and Barbara Hepworth.

Presented by Phillip Ball.

Picture: Corn shell, Getty Images

How do we prepare for the distant future? Helen Keen meets the people who try to.

If our tech society continues then we can leave data for future generations in huge, mundane quantities, detailing our every tweet and Facebook 'like'. But how long could this information be stored? And if society as we know it ends, will our achievements vanish with it? How do we plan for and protect those who will be our distant descendants and yet may have hopes, fears, languages, beliefs, even religions that we simply cannot predict? What if anything can we, should we, pass on?

Picture: Filing cabinets, Credit: fotofrog

Male circumcision is one of the oldest and most common surgical procedures in human history. Around the world, 1 in 3 men are cut. It’s performed as a religious rite in Islam and Judaism; in other cultures it’s part of initiation, a social norm or marker of identity. Some individuals think it’s cleaner, sexier or safer. In this documentary, anthropologist Mary-Ann Ochota explores the reasons we cut men. She meets people who passionately promote the practice – and others who protest against it.

Across sub-Saharan Africa, medical circumcision is endorsed in the fight against HIV – research shows it reduces the risk of a man getting infected if he has sex with an HIV-positive woman. More than 10 million men and boys have been circumcised so far; officials plan to reach another 25 million by 2020.

In rural Uganda, Mary-Ann visits a mobile clinic to watch 21-year-old Wajuli undergo the operation. She meets another young man in Kampala who reveals his regret about getting cut.

The United States is the only western country where most boys are circumcised for non-religious reasons – $270 million a year is spent on infant circumcision. In downtown New York, Mary-Ann meets ‘Intact-ivists’ who believe male circumcision is genital mutilation. She speaks to members of the public confronted with the protest, and interviews a leading US paediatrician who reflects on the reasons US doctors keep cutting.

With contributions from Uganda’s national VMMC coordinator Dr Barbara Nanteza, Dr Marc Cendron (Boston Children’s Hospital) and Georganne Chapin, Intact America.

Picture: Intactivist van in Union Square, New York, Credit: Nick Minter

The phrase 'essential 'element' is often incorrectly used to describe the nutrients we need, but can aptly be applied to iodine - without it we would suffer severe developmental problems. Iodine is a key component of thyroid hormones, responsible for the regulation of our metabolism. And yet most of us have no idea how much we need, nor where it comes from.

In her research, Margaret Rayman, Professor of Nutritional Medicine at Surrey University, has found pregnant women in particular are at risk of iodine deficiency - and there's a lack of iodine in what many consider healthy diets.

As well as looking at contemporary issues with iodine, Margaret explores the legacy of past iodine deficiency - the word cretin, was coined to describe someone living in the Alps with such a condition. We learn why you might find iodine in British milk - but not necessarily elsewhere in the world, and we discuss the consequences of exposure to radioactive iodine isotopes - both good and bad.

Picture: Pregnant woman with milk, Credit: Arief-Juwono/Getty Images

What links trade unions with urine, Syria with semiconductors, and bones and bombs? The answer is phosphorus, UCL Inorganic Chemistry Professor Andrea Sella, who is himself engaged in researching new phosphorus based materials, looks at this often rather frightening element. We hear how the health impact of phosphorus on a group of Irish girls changed politics, how the element has been used as a weapon of war and we peer into the future, as chemists break new ground on what might be possible with phosphorus and nanotechnology.

Photo: BBC Copyright

From the plumbing of ancient Rome, to lead acid batteries, paint, petrol and a dangerous legacy, the metal lead has seen a myriad of uses and abuses over thousands of years. In bullets, and poisons it has killed us both quickly and slowly, and yet its malleability, low melting point and resistance to corrosion make it a fantastic material for all kinds of containers and water proofing. And it is key to one of the most commonly used, and ignored, devices on the planet, the car battery.

However it's only recently that the serious impact of lead poisoning on the development of children's brains has come to light. Uta Frith, Emeritus Professor of Cognitive Development at University College London, who studied the impact of lead poisoning in the 1970s and 80s, journeys with lead from the iron age to the present day delving into the history and scandal associated with this often overlooked element.

Photo: BBC Copyright

Zoologist and founder of the Sloth Appreciation Society, Lucy Cooke, unleashes her inner sloth to discover why being lazy could actually be the ultimate evolutionary strategy.

The explorers of the New World described sloths as ‘the lowest form of existence’, but sloths are actually some of the most enduring of all tropical mammals. They make up one third of the mammalian biomass in rainforests and have survived some 64 million years - outliving far flashier animals like sabre tooth tigers.

The secret to the sloth’s success is their slothful nature and their suite of energy-saving adaptations. In fact slothfulness is such a successful strategy, that there are examples all over the animal kingdom, including, surprisingly, worker ants. Recent studies in humans have shown the many health benefits of adopting a slower pace of life. Sleep itself is universal amongst the animal kingdom. All animals do it, but why remains a mystery. What is clear though, is that unleashing your inner couch potato is no bad thing, be you sloth or human.

Lucy discovers the genius behind the sloths laid back attitude and fights the corner for laziness.

Producer: Alexandra Feachem

Picture: A young two-toed sloth sits in a bucket, September 2017. Credit: Klaus-Dietmar Gabbert / AFP / Getty Images

Does knowing that someone is inflicting pain on you deliberately make the pain worse? Professor Irene Tracey meets survivors of torture and examines the dark side of pain.

Producer: Geraldine Fitzgerald

(Photo: A woman mourns during the funeral procession of Abdulrassul Hujairi. Credit: Joseph Eid/AFP)

What if your brain could naturally control pain? Professor Irene Tracey and her colleagues are trying to unlock the natural mechanisms in the brain that limit the amount of pain we feel.

We hear about how children learning judo are taught special techniques and from ex-marine Chris Shirley who ran a marathon carrying a 45kg rucksack and could ignore the pain of the blisters and torn shoulder muscles. One study found that religious people feel less pain than agnostics by looking at a picture of the Virgin Mary. Neuroscientists and psychologists are beginning to understand how this is possible, how the brain can block out pain in the right circumstances, so is this something we could all benefit from?

Picture: The statue of the Virgin Mary, Credit: Francisco Leong/AFP/Getty Images

Producer Geraldine Fitzgerald

Scientists reveal why we feel pain and the consequences of life without pain. One way to understand the experience of pain is to look at unusual situations which give clues to our everyday agony.

Phantom limb pain was described in ancient times but only after WWI did it gain acceptance in modern medicine. For those living with it, it can be a painful reminder of a lost limb. New studies are now unravelling why the brain generates this often unpleasant experience and how the messages can be used positively.

Its only since the 1980s that doctors agreed that babies are able to feel pain but we still don’t know how the developing brain processes information and how premature babies can be protected from the many invasive tests they have to go through. New research aims to provide appropriate pain relief that could have long term consequences.

Picture: Nerve cells, computer artwork, Credit: Science Photo Library

Mystery still surrounds the experience of pain. It is highly subjective but why do some people feel more pain than others and why does the brain appear to switch off under anaesthesia so we are unaware of the surgeon’s scalpel? Professor Irene Tracey uses brain scanners to ask if we can actually see pain in the brain. On air we hear for the first time the results of the latest research into diabetes and nerve pain. Promising new techniques means scientists are able to see regions in the brain which effectively turn up the pain in some people and not others.

Anaesthetics prevent pain during surgery but how the brain disengages is only just beginning to be understood, which could in the future lead to personalised doses of anaesthetics leading to faster recovery times.

Picture: Graphic of neurons firing in the of the neural network within the Brain, Credit: Science Photo Library

In Bristol in 1799, a young man started to experiment with newly discovered gases, looking for a cure for tuberculosis. Humphry Davy, aged 20, nearly killed himself inhaling carbon monoxide. Nitrous oxide was next. It was highly pleasurable, ‘particularly in the chest and extremities’ and he began to dance around his laboratory ‘like a madman’, before passing out. By day, he gave the gas to patients, carefully noting their reactions. In the evenings, he invited his friends over to have a laugh (with assistants on standby to revive them with oxygen, as needed). The Romantic poets, Robert Southey and Samuel Taylor Coleridge could barely contain their excitement. During one session, Davy noted that the gas numbed his toothache and suggested that it could perhaps be used during surgical operations. But it was another fifty years before nitrous oxide was used by doctors. Throughout the 20th century, it was widely used during dentistry and to numb the pain of childbirth. (Nitrous oxide is the gas in ‘gas and air’: the ‘air’ is oxygen) .And it still is today, but less so. (It’s a potent greenhouse gas that damages the ozone layer, it’s difficult to store and there are side-effects). But, just as medical use is diminishing, recreational use is on the rise. A new generation of pleasure seekers have started experimenting, just as Davy did, despite the associated risks of injuries caused by fainting and death by suffocation. Naomi Alderman tells how a gas that created ‘ecstatic lunatics’ came to be used as an anaesthetic, with help from biographer, Richard Holmes and anaesthetist, Kevin Fong.

Picture: Humphry Davy and Anaesthesia, Credit: Science Photo Library

Philip Ball reveals the dramatic tale of Lise Meitner, the humanitarian physicist of Jewish descent, who unlocked the science of the atom bomb after a terrifying escape from Hitler's Germany. One of the most brilliant nuclear scientists working in Germany her flight from terror cost Hitler’s regime dearly.

In the early 20th Century it was barely possible for women to work in science at all and yet Einstein once called Meitner Germany’s own Marie Curie. It was Meitner’s insight that began the nuclear age and her story remains ever relevant, as the threat of nuclear conflict lies once again over the world.

Philip Ball talks to historian Dr Patricia Fara about Lise Meitner and her research and to Patricia Lewis of the International Campaign to Abolish Nuclear Weapons or ICAN, based in Geneva, which this year was awarded the Nobel Peace prize for its work in trying to reverse nuclear proliferation, about Meitner’s legacy today.

Picture: Lise Meitner, Credit: Central Press/Getty Images

Roland Pease tells the story of how fifty years ago geologists finally became convinced that the earth’s crust is made up of shifting plates. The idea of mobile continents, continental drift, had been talked about, for example because it looked like Africa and South America had once been joined, and were now separated by the Atlantic. But given the solidity of rocks and the vastness of continents, that idea made no sense. Until plate tectonics, as it became known, gave it a scientific basis and rebuilt it into a mechanism that explained earthquakes, mountain belts, chains of volcanic islands and many other geological phenomena. Roland Pease talks to many of the key researchers in the story, now in their 70s and 80s, and finds out how their work transformed our understanding of the earth.

Picture: Tectonic plates of planet earth - map with names of major and minor plates, Credit: PeterHermesFurian

Presenter: Roland Pease

Maria Merian was born in 1647. At the time of her birth, Shakespeare had been dead for 30 years; Galileo had only just stood trial for arguing that the Earth moved around the Sun. And yet, here in Germany, was a child who would become an important but oft-forgotten figure of science.

Aged 13, she mapped out metamorphosis, catching caterpillars from her garden and painting them in exquisite detail. At that point, most believed that caterpillars spontaneously generated from cabbages and maggots materialised from rotten meat. She later voyaged to Suriname in South America to pursue pupae further, discovering not just new species but also the conditions needed for their survival.

Some call her the first field ecologist; others admire her for her eloquent brushwork. However, her studies will help today’s biologists plot which insects lived where. These data are invaluable because this could help scientists predict what species will survive climate change.

Naomi Alderman discusses the life and legacy of Maria Merian with biologist and historian Kay Etheridge from Gettysburg College, Pennsylvania and biologist Kathy Willis from Kew Gardens.

Picture: Belly-ache bush (Jatropha gossypifolia) with metamorphosis of a giant sphinx moth (Cocytius antaeus), created by Maria Sibylla Merian and Joseph Mulder, Credit: GRI Digital Collections

Producer: Graihagh Jackson

The Dark Ages are often painted as an era of scholarly decline. The Western Roman Empire was on its way out, books were few and far between, and, if you believe the stereotype, mud-splattered peasants ran around in rags.

However, it was far more intellectually vibrant than you might imagine. Out of this era emerged a set of ‘problems to sharpen the young,’ including the famous river crossing puzzle that’s still taught in maths today. The presumed author of these riddles is Alcuin of York – ‘the most learned man in the world.’ And it was this monk and his puzzles that laid the foundations for a branch of mathematics called combinatorics – the thinking behind today’s computer coding and cryptography.

Philip Ball speaks to historian Mary Garrison from the University of York to learn of Alcuin's character and how he encouraged his students to learn for the sake of learning, as opposed to salvation. And University College London mathematician Hannah Fry shows Philip just how much of a role combinatorics plays in today’s world.

Picture: White horned goat chewing a cabbage leaf, Credit: Oxana Medvedeva

Producer: Graihagh Jackson

All countries are supposed to measure and report their greenhouse gas emissions but BBC environment correspondent, Matt McGrath, reveals there are gaping holes in national inventories. He uncovers serious failings in countries’ accounts of warming gases with many not reporting at all. There are disturbing signs that some banned warming chemicals, which are supposed to have been phased out completely, are once again on the rise. And evidence that worthless carbon credits are still being traded. Meanwhile scientists are growing increasingly frustrated by the refusal of countries to gather and share accurate data in the face of this planetary emergency

(Photo: The Jungfraujoch Air Monitoring Station in Switzerland. Credit: Jungfraujoch)

Every three seconds someone is diagnosed with dementia, and two thirds of the cases are Alzheimer’s Disease. As the global population ages, this is becoming an epidemic, and with no cures currently available for the collection of neurodegenerative conditions that include Alzheimer’s, Parkinson’s and Motor Neurone Disease the public and personal cost is escalating. Sue Broom reports on new efforts to find ways to stop the progress of these diseases for the first time, and to bring treatment for neurodegenerative conditions in line with those of cancer and heart disease.

Picture: Human head, Credit: Science Photo Library

Presenter: Sue Broom

Two deadly cases today sent in by listeners to curiouscases@bbc.co.uk

The Dark Star "What's inside a black hole and could we fly a spaceship inside?" asks Jorge Luis Alvarez from Mexico City.

Astrophysicist Sheila Rowan explains how we know invisible black holes actually exist. Plus cosmologist Andrew Pontzen is on hand to help cook one up.

But which of our intrepid doctors will volunteer to fly into the heart of a black hole?

Kate Bush’s Sonic Weapon "It started while listening to the excellent Experiment IV by Kate Bush. The premise of the song is of a band who secretly work for the military to create a 'sound that could kill someone'. Is it scientifically possible to do this?" asks Paul Goodfield.

Hannah consults acoustic engineer Trevor Cox to ask if sonic weapons could kill. And Adam delves into subsonic frequencies with parapsychologist Chris French to investigate their spooky effects.

Plus the team investigates the Curious Case of the Embassy in Cuba – could a sonic weapon really be responsible for the wide-ranging symptoms reported by American diplomats in Havana?

You can send your scientific mysteries for the team to investigate to: curiouscases@bbc.co.uk

Picture: A computer-generated image of a rich star field with a Black Hole in front of it which distorts starlight into a brilliant ring around itself, Credit: BBC

Producer: Michelle Martin

The Polar Opposite No one knows why the Earth's magnetic North and South poles swap. But polar reversals have happened hundreds of times over the history of the Earth. John Turk emailed curiouscases@bbc.co.uk to ask, “when is the next pole swap due and what will happen to us?” Featuring Prof Lucie Green from Mullard Space Science Laboratory and Dr Phil Livermore from the University of Leeds. Plus, astronaut Terry Virts, author of The View from Above, describes his experiences of a strange magnetic glitch in the earth's magnetic field, known as The Bermuda Triangle of Space.

The World That Turns "Why does the Earth spin?" asks Joe Wills from Accra in Ghana. Hannah quizzes cosmologist Andrew Pontzen about the birth of the Solar System. BBC weatherman John Hammond describes the curious things that would happen if the Earth spun the opposite way. Send your questions to: curiouscases@bbc.co.uk

Picture: The Earth reflecting light from the sun whilst aboard the International Space Station, Credit: Alexander Gerst / ESA via Getty Images

Producer: Michelle Martin

The Astronomical Balloon "How far up can a helium balloon go? Could it go out to space?" asks Juliet Gok, aged 9. This calls for an experiment! Dr Keri Nicholl helps Adam launch a party balloon and track its ascent. But their test doesn't quite go to plan. Meanwhile, Hannah discovers where space begins by asking Public Astronomer Dr Marek Kukula, from the Royal Observatory Greenwich. Send your Curious Cases to the team: curiouscases@bbc.co.uk

The Forgetful Child "Why don't we remember the first few years of our lives?" asks David Foulger from Cheltenham. The team investigate the phenomenon of 'infant amnesia' with Catherine Loveday from the University of Westminster. 40% of us claim to remember being under two years old and 18% recall being babies. But can we really trust these early memories? Martin Conway from City University thinks not.

Picture: Baby Foot, Credit H. Armstrong Roberts/Retrofile/Hulton Archive/Getty Images

Producer: Michelle Martin.

The Astronomical Balloon "How far up can a helium balloon go? Could it go out to space?" asks Juliet Gok, aged 9. This calls for an experiment! Dr Keri Nicholl helps Adam launch a party balloon and track its ascent. But their test doesn't quite go to plan. Meanwhile, Hannah discovers where space begins by asking Public Astronomer Dr Marek Kukula, from the Royal Observatory Greenwich. Send your Curious Cases to the team: curiouscases@bbc.co.uk

The Forgetful Child "Why don't we remember the first few years of our lives?" asks David Foulger from Cheltenham. The team investigate the phenomenon of 'infant amnesia' with Catherine Loveday from the University of Westminster. 40% of us claim to remember being under two years old and 18% recall being babies. But can we really trust these early memories? Martin Conway from City University thinks not.

Picture: A baby contemplates the sole of its foot, circa 1950, Credit: H. Armstrong Roberts/Retrofile/Hulton Archive/Getty Images

Producer: Michelle Martin.

“How on earth do cats find their way back to their previous home when they move house?" asks Vicky Cole from Nairobi in Kenya.

Our enduring love for our feline friends began when Egyptian pharaohs began to welcome domesticated moggies into their homes. Pictured reclining in baskets at the feet of royalty, pet cats soon became fashionable throughout society in Egypt. Today they are the most popular pet in the world, and home is definitely where their hearts lie.

"Whereas dogs are bonded to people, cats are bonded to place," explains zoologist Dr John Bradshaw. "It's very typical for them to try and find their way back to their old house when you move."

But how do they do it? And if their navigational skills are so good, why do they get lost? Prof Matthew Cobb reveals the super-senses that cats possess, and how to spot when your pet is deploying them.

Itchy and Scratchy "What is an itch and how does scratching stop it? Why does scratching some itches feel so good?!" asks Xander Tarver from West Sussex in England.

Our doctors set off to probe the mysteries of itch, and discover that this overlooked area of medicine is revealing surprising results about the human brain. From why itching is contagious to why scratching is pleasurable, we get under the skin of this medical mystery.

The programme features interviews with neuroscientist Prof Francis McGlone from Liverpool John Moores University and dermatologist Dr Brian Kim from the Center for the Study of Itch at Washington University. Yes, that is a real place.

If you have any Curious Cases for the team to solve please email curiouscases@bbc.co.uk.

Presenters: Adam Rutherford, Hannah Fry Producer: Michelle Martin

(Photo: Cat, Credit: Chris J Ratcliffe/Getty Images)

Science sleuths Drs Rutherford & Fry take on everyday mysteries and solve them with the power of science. Two cases in this episode concerning the inner workings of our bodies, and not for the faint hearted! The Broken Stool "Science tells us that our body houses microbial organisms. Then how much our weight is really our weight? If I am overweight, is it because of my own body cells or excess microflora?" asks Ajay Mathur from Mumbai in India.

Adam bravely sends off a personal sample to the 'Map My Gut' project at St Thomas' Hospital to have his microbes mapped. Prof Tim Spector reveals the shocking results - a diet of fried breakfasts and fizzy drinks has left his guts in disarray. But help is at hand to makeover his bacterial lodgers.

Science writer Ed Yong, author of 'I Contain Multitudes', reveals how much our microbes weigh. We're just beginning to discover the vast array of vital functions they perform, from controlling our weight, immune system and perhaps even influencing our mood and behaviour. A Code in Blood "Why do we have different blood types?" asks Doug from Norfolk in the UK.

The average adult human has around 30 trillion red blood cells, they make up a quarter of the total number of cells in the body.

We have dozens of different blood groups, but normally we're tested for just two - ABO and Rhesus factor. Adam and Hannah delve into the gory world of blood and the early history of blood transfusions, to discover why we have blood groups and how they differ around the world.

Featuring interviews with Dr Jo Mountford, from the Scottish National Blood Transfusion Service and immunologist Dr Sheena Cruikshank from the University of Manchester.

If you have any Curious Cases for the team to solve please email curiouscases@bbc.co.uk.

Presenters: Adam Rutherford, Hannah Fry Producer: Michelle Martin

Image: Illustration of red blood cells in a blood vessel. Copyright: Science Photo Library

Sydney Brenner was one of the 20th Century’s greatest biologists. Born 90 years ago in South Africa to impoverished immigrant parents, Dr Brenner became a leading figure in the biological revolution that followed the discovery of the structure of DNA by Crick and Watson, using data from Rosalind Franklin, in the 1950s. Brenner’s insights and inventive experiments laid foundation stones for new science of molecular biology and the genetic age in which we live today, from the Human Genome Project to gene editing. Sydney Brenner talks to biologist and historian Matthew Cobb of the University of Manchester about this thrilling period in biological science, and Dr Brenner’s 20 year-long collaboration with DNA pioneer Francis Crick: a friendship which generated some of their most creative research.

Producer: Andrew Luck-Baker

Picture: Sydney Brenner, Credit: Cold Spring Harbor Lab Archive

This is a big story about a little snail. Biologist Helen Scales relates an epic tale that spans the globe and involves calamity, tragedy, extinction and we hope, salvation. It stars the tiny tree-dwelling mollusc from French Polynesia, Partula, a snail that has captivated scientists for centuries. Like Charles Darwin studied finches on the Galapagos, Partula became an icon of evolution because, in the living laboratories of the Pacific islands, it had evolved into multiple species. But a calamity drove Partula to extinction, when a botched biological control, the predatory Rosy Wolf Snail, was introduced. It was supposed to eat another problem mollusc, but in a cruel twist, devoured tiny Partula instead. An international rescue mission was scrambled to save a species and from just one or two rescued individuals, populations of this snail species have been built up over thirty years in captive breeding programmes in zoos around the world. And now, in the nailbiting sequel, we track Partula’s journey home.

Picture: Reintroduced Partula dispersing on Moorea in French Polynesia, Credit: ZSL

Presenter: Helen Scales Producer: Fiona Hill

For more than 200 years Britain ruled India, bringing many aspects of British culture to India - including European science developed during the enlightenment. However centuries earlier India had already pioneered work in astronomy, mathematics and engineering.

How was India’s scientific progress affected by colonialism? Did British rule hold the country back, or did it drive it forward? Presented by Angela Saini.

Picture: The Indian Space Research Organisation (ISRO) communication satellite GSAT-19, carried onboard the Geosynchronous Satellite Launch Vehicle (GSLV-mark III ), launches at Sriharikota on June 5, 2017, Credit: ARUN SANKAR/AFP/Getty Images

We go behind the scenes of a new exhibition on India at London’s Science Museum. What can historical objects tell us about India’s rich, and often hidden scientific past? We look at the influential mathematics, metallurgy and civil engineering of ancient India.

The exhibition also contain artefacts from India’s time under the British Empire. We ask how the many years of colonial rule shaped the more recent scientific development of India.

Science journalist Angela Saini presents.

Image: Bakhshali manuscript, Credit: Bodleian Library

Can Africa’s Great Green Wall beat back the Sahara desert and reverse the degrading landscape? The ambitious 9 miles wide and 5000 miles long line of vegetation will stretch all the way from Dakar in the west to Djibouti in the east.

Thomas Fessy is in Senegal where the wall has already begun to evolve into a series of forests and garden communities. He meets the planners, planters, ecologists and local villagers to hear how its early progress is reversing years of poor land use, turning nomads back to farmers, empowering women and creating healthy ecosystems for rain fed agriculture.

But can it meet its ambition to stabilize an unstable region, reverse the growing trend of migration, fight the effects of climate change and ensure this big African dream doesn’t die in the sand?

Picture: The Great Green Wall, credit: BBC

Producer Adrian Washbourne

Can we Control the Dark Side of the Internet?

The Internet is the world's most widely used communications tool. It’s a fast and efficient way of delivering information. However it is also quite dumb, neutral, treating equally all the data it passes around the world. From data that forms scientific research papers, the wealth of social media to keep us all connected with friends and relatives, entertainment or material we would rather not see- from political propaganda to horrific violence, the Internet makes no distinction.

Is it time to change that? And can we? In this programme Aleks Krotoski looks at whether it’s possible to use technological fixes to regulate the internet or whether a more political approach is needed to governance of this vital but flawed communications medium.

Picture: Human Hand Using Application on Mobile Phone, Credit: Onfokus

With the coming of the World Wide Web in the 1990s internet access opened up to everybody, it was no longer the preserve of academics and computer hobbyists. Already prior to the Web, the burgeoning internet user groups and chat rooms had tested what was acceptable behaviour online, but access was still limited.

Aleks Krotoski asks whether the Web through enabling much wider use of the internet is the villain of the piece in facilitating not just entertainment and commerce, but all aspects of the darker side, from malicious computer hacking attacks, worms and viruses, to new channels for criminality, online extortion and identity theft.

(Photo: Internet sign. Credit: code6d)

Just how did the Internet become the most powerful communications medium on the planet, and why does it seem to be an uncontrollable medium for good and bad? With no cross border regulation the internet can act as an incredible force for connecting people and supporting human rights and yet at the same time convey the most offensive material imaginable. It has become the most useful research tool on earth but also the most effective way of delivering threats to the security of governments, the health service and on a personal level our own identities.

In this series Aleks Krotoski unravels the complexity of the internet, meeting the people who really invented it, looking behind the myths and cultural constructs to explain what it actually is and how it came to exist outside of conventional regulation. We’ll ask whether the nature of the net itself really is cause for concern - and if so what can be done to reign in the negatives of the internet without restricting the positives?

In this first episode we go back to the days before the internet to look at the cultural and technological landscape from which it grew, and unravel some of the key moments - now lost in time and obscured by technology folklore, which mark when the internet lost its innocence.

Picture: Mechanical computer keyboard blurred, credit: OSchaumann/Getty

Silicon is literally everywhere in both the natural and built environment, from the dominance of silicate rocks in the earth crust, to ubiquitous sand in building materials and as the basis for glass.

We've also harnessed silicon's properties as a semiconductor to build the modern electronics industry - without silicon personal computers and smartphones would simply not exist.

Silicon is also found widely across the universe. It is formed in stars, particularly when they explode. And the similarities between how silicon and carbon form chemical bonds has led many to wonder whether there could be silicon based life elsewhere - perhaps in some far flung part of the galaxy where carbon is not as abundant as here on earth.

As well as discussing the potential for silicon based life on other planets, Birkbeck University astrobiologist Dr Louisa Preston considers the varied uses of silicon here on earth, from its dominance in our built environment to its driving role in artificial intelligence and its ability to harness the sun's energy.

Image: Lump of silicon on solar panels Credit: wloven/Getty Images

For the first time in almost 100 years the USA is experiencing a full solar eclipse from coast to coast on August 21st 2017.

Main image: Totality during the solar eclipse at Palm Cove on November 14, 2012 in Palm Cove, Australia. Credit: Ian Hitchcock / Getty Images

Carbon is widely considered to be the key element in forming life. It's at the centre of DNA, and the molecules upon which all living things rely.

Monica Grady, Professor of Planetary Science at the Open University, explores the nature of carbon, from its formation in distant stars to its uses and abuses here on earth.

She looks at why it forms the scaffold upon which living organisms are built, and how the mechanisms involved have helped inform the development of new carbon based technology, and products - from telephones to tennis rackets.

One form of carbon is graphene which offers great promise in improving solar cells and batteries, and introducing a whole new range of cheaper more flexible electronics.

Carbon is also the key component of greenhouse gases, carbon dioxide and methane. To counter some of the effects of man-made climate change, Scientists are now developing novel ways to speed up this mechanism - using waste materials created from mining and industry.

Monica Grady also looks to space, and the significance of carbon in the far reaches of the universe. There is lots of carbon in space, some in forms we might recognise as the precursors to molecules. As elemental carbon seems to be everywhere what are the chances of carbon based life elsewhere?

Image: Steam and exhaust rise from the chemical company Oxea (front) and the coking plant January 6, 2017 in Oberhausen, Germany. Photo by Lukas Schulze Getty Images

From the origins of the universe, though batteries, glass and grease to influencing the working of our brains, neuroscientist Sophie Scott tracks the incredible power of lithium.

It's 200 years ago this year that lithium was first isolated and named, but this, the lightest of all metals, had been used as a drug for centuries before.

From the industrial revolution it proves its worth as a key ingredient in glass and grease, and as the major component in lithium ion batteries it powers every smartphone on the planet.

In mental health lithium has proved one of the most effective treatments. And its use to treat physical ailments is now making a comeback.

We explore how the chemistry of lithium links all these apparently unrelated uses together.

Main Image: Lights from mobile phones in Bucharest on February, 2017. Credit: ANDREI PUNGOVSCHI / AFP / Getty Images )

Oxygen appeared on Earth over two billion years ago and life took off. Now it makes up just over a fifth of the air. Trevor Cox, professor of acoustic engineering at the University of Salford, England, tells the story of oxygen on Earth and in space.

Without oxygen, there would be no life on Earth, yet it was not discovered until late in the 18th Century. During the Great Oxidation Event, three billion years ago, cyanobacteria, thought to be the earliest forms of life on our planet, started to photosynthesise and these tiny creatures were responsible for putting the oxygen into our atmosphere, so we can breathe today. But it is not just for breathing. Ozone is three atoms of oxygen, and when it is in the stratosphere it stops harmful UVB rays from the sun reaching us. And if we are ever to leave our home planet, we will need to find a way to generate enough oxygen to keep us alive.

Trevor visits the Science Museum in London, to discover how astronauts on the space station get their oxygen. Trevor Cox is not only an acoustic engineer, he also plays the saxophone. When he finds out the role that oxygen, in the air, has on the sound of his playing he gets a surprise.

(Photo: Hovering clouds near Nagqu, approx 4,500 meters above sea level, north of Lhasa on the Tibetan plateau. Credit: Frederic J Brown/ AFP/Getty Images)

The most beautiful and shimmering of the elements, the weirdest, and yet the most reviled.

Chemist Andrea Sella tell the story of Mercury, explaining the significance of this element not just for chemistry, but also the development of modern civilisation.

It's been a a source of wonder for thousands of years - why is this metal a liquid? and what is its contribution to art, from the Stone Age to the Renaissance?

We look at how Mercury is integral to hundreds of years of scientific discoveries, from weather forecasting to steam engines and the detection of atomic particles it has a key role.

However Mercury is highly toxic in certain forms and ironically the industrial processes it helped create have led to global pollution which now threatens fish, wildlife and ourselves.

We ask is it time to say goodbye to Mercury?

Picture: Hg, mercury metal drops, credit: AlexeyVS/Getty Images

Anu Anand is in Lyon, looking at what we eat and drink and the risk of bowel cancer

Anu Anand on detecting and treating prostate cancer in Trinidad and Tobago.

Anu Anand explores why more black women are more likely to die of breast cancer in the US

Anu Anand on how vinegar and a head torch are used to tackle cervical cancer in Tanzania

For more than 65 years we have known that smoking kills. So how can it be that a Mexican wave of tobacco use, disease and death is heading at breakneck speed towards the world’s poorest people? Millions will die of lung cancer and it is hard to grasp that this is a largely preventable disease.

Uruguay in South America could hold the key to breaking this wave. Under a President who is a cancer specialist they introduced some of the most radical tobacco control policies in the world and attracted the wrath of corporate tobacco giant, Philip Morris, in the process. Anu Anand reports on Uruguay’s crusade to save its citizens.

Image: Roberto, life long smoker who has lung cancer Credit: Anu Anand

The Mongolian matriarch who is helping people with terminal liver cancer die in comfort

From Skynet and the Terminator franchise, through Wargames and Ava in Ex Machina, artificial intelligences pervade our cinematic experiences. But AIs are already in the real world, answering our questions on our phones and making diagnoses about our health. Adam Rutherford asks if we are ready for AI, when fiction becomes reality, and we create thinking machines.

Robots are becoming present in our lives, as companions, carers and as workers. Adam Rutherford explores our relationship with these machines. Have we made them to be merely more dextrous versions of us? Why do we want to make replicas of ourselves? Should we be worried that they could replace us at work? Is it a good idea that robots are becoming carers for the elderly?

Adam Rutherford meets some of the latest robots and their researchers and explores how the current reality has been influenced by fictional robots from films. He discusses the need for robots to be human like with Dr Ben Russell, curator of the current exhibition of robots at the Science Museum in London. In the Bristol Robotics Laboratory Adam meets Pepper, a robot that is being programmed to look after the elderly by Professor Praminda Caleb-Solly. He also interacts with Kaspar, a robot that Professor Kerstin Dautenhahn at the University of Hertfordshire has developed to help children with autism learn how to communicate better.

Cultural commentator Matthew Sweet considers the role of robots in films from Robbie in Forbidden Planet to the replicants in Blade Runner. Dr Kate Devlin of Goldsmiths, University of London, talks about sex robots, in the past and now. And Alan Winfield, Professor of Robot Ethics at the Bristol Robotics Laboratory, looks ahead to a future when robots may be taking jobs from us.

Image; BBC ©

The idea of robots goes back to the Ancient Greeks. In myths Hephaestus, the god of fire, created robots to assist in his workshop. In the medieval period the wealthy showed off their automata. In France in the 15th century a Duke of Burgundy had his chateau filled with automata that played practical tricks on his guests, such as spraying water at them. By the 18th century craftsmen were making life like performing robots. In 1738 in Paris people queued to see the amazing flute playing automaton, designed and built by Jacques Vaucanson.

With the industrial revolution the idea of automata became intertwined with that of human workers. The word robot first appears in a 1921 play, Rossum's Universal Robots, by Czech author Carel Chapek.

Drawing on examples from fact and fiction, Adam Rutherford explores the role of robots in past societies and discovers they were nearly always made in our image, and inspired both fear and wonder in their audiences. He talks to Dr Elly Truitt of Bryn Mawr College in the US about ancient and medieval robots, to Simon Shaffer, Professor of History of Science at Cambridge University and to Dr Andrew Nahum of the Science Museum about !8th century automata, and to Dr Ben Russell of the Science Museum about robots and workers in the 20th century. And Matthew Sweet provides the cultural context.

Picture credit: BBC

IBM is giving users worldwide the chance to use a quantum computer; Google is promising "quantum supremacy" by the end of the year; Microsoft's Station Q is working on the hardware and operating system for a machine that will outpace any conventional computer. Roland Pease meets some of the experts, and explores the technology behind the next information revolution.

Picture: Bright future for Quantum Computing, credit: Jonathan Home @ETH

Synthetic biology, coming to a street near you. Engineers and biologists who hack the information circuits of living cells are already getting products to the market. Roland Pease meets the experts who are transforming living systems to transform our lives.

Picture: MIT spinout Synlogic is re-programming bacteria found in the gut as "living therapeutics" to treat major diseases and rare genetic disorders, courtesy of Synlogic

As a small rocky planet, Mars is similar in many respects to the Earth and for that reason, many have thought it may harbour some kind of life. A hundred years ago, there was serious talk about the possibility of advanced civilisations there. Even in early 1970s, scientists mused that plant-like aliens might grow in the Martian soil. The best hope now is for something microbial. But the discovery that even simple life survives there or did some time in its history would be a profound one. We would know that life is not something special to Earth.

NASA’s Curiosity rover has discovered that 3.7 billion years ago, there were conditions hospitable to life on Mars – a sustained period of time with lakes and rivers of water. The earlier rover Spirit found deposits of silica from ancient hot springs which some planetary scientists argue bear the hallmarks of being shaped by microbes - possibly.

The next five years may dramatically advance the hunt for life on Mars. In 2020 the European and Russian space agencies will send their ExoMars rover. That will drill two metres into the Red Planet’s surface and sample material shielded from the sterilising radiation. It will analyse for life both extant and extinct. In the future, robotic or possibly human missions may even explore Martian cave systems in Mars' vast volcanoes. Monica talks to Nasa's Penny Boston whose adventures in some of the world's most dangerous caves have convinced her that underground is the best place to look.

Monica Grady is Professor of Planetary and Space Science at the Open University.

Credit: Curiosity in Gale Crater, credit NASA-JPL

Producer: Andrew Luck-Baker

In Lifechangers, Kevin Fong talks to people about their lives in science.

Major General Charles Bolden – a former NASA administrator – talks to Kevin Fong about his extraordinary life, from childhood in racially segregated South Carolina to the first African American to command a space shuttle. He had originally hoped to join the Navy, but was unable to as an African American. Although Charles refused to take no for an answer and after much petitioning he was accepted. From there he reached for the stars.

Image: Charlie Bolden, © Alex Wong/Getty Images

In Lifechangers, Kevin Fong talks to people about their lives in science.

Astrophysicist and Director of the Hayden Planetarium in New York City, Neil deGrasse Tyson is well known in the US since he presented the TV series Cosmos: a spacetime odyssey. He talks to Kevin Fong about growing up in Brooklyn, becoming obsessed with the night sky and how he became a broadcaster and writer.

Image: Neil deGrasse Tyson, © Cindy Ord/Getty Images for FOX

In the start of a new series of Lifechangers, Kevin Fong talks to three people about their lives in science.

His first conversation is with a man better known for his life in science fiction, George Takei, the Japanese American actor who played Sulu in the TV series, Star Trek. They discuss the voyages of the Starship Enterprise and the ideas of other worlds featured in Star Trek. He talks about his own epic life journey – how his family was imprisoned when the US joined the Second World War and his campaigning against social injustice.

Photo: George Takei making the Live Long and Prosper symbol, © Suhaimi Abdullah/Getty Images

Bees pollinate and can detect bombs and compose music. What would we do without them? The world owes a debt of gratitude to this hard working but under-appreciated insect. One third of the food we eat would not be available without bees, meaning our lives would be unimaginably different without them.

Bee populations are dropping by up to 80% in some countries and the consequences are potentially catastrophic. The use of neonics pesticides in farming has been one of the main causes in the decline in bee numbers and now the farming world is having to take drastic action to try and reverse the trend. The situation has become so dire in some parts of China that the government set up a scheme in which humans had to pollinate plants by hand. Researchers in America have been so worried about a world without bees that they have started to develop robotic 'insects' to emulate their work. What’s causing the drop in populations and what might save them? Dr George McGavin hears from scientists and researchers in Africa, South America, Europe and Asia about the extraordinary lives and impact of bees, hearing the amazing ways in which they communicate and learn, and how complex and diverse different bee species are.

Since the birth of Louise Brown - the world’s first IVF baby - in England in 1978, many children have been born through in vitro fertilisation. IVF doesn’t work for everyone but over the last few decades basic research into human reproduction has brought about huge improvements.

In the UK the Human Fertilisation and Embryology Act, passed in 1990, made it illegal for research on human embryos to be permitted beyond 14 days. In a dozen other countries, from Canada and Australia to Iceland and South Korea the 14 day limit is enshrined in law and in five others, including China, India and the US, there are guidelines that recommend that limit.

Just recently researchers at Cambridge University have kept embryos alive in the lab for 13 days. They and others are calling for the limit to be extended for another one or two weeks, so they can study why early pregnancies fail. Matthew Hill reports on the issues raised by these new developments in embryo research.

Image: Light micrograph of fertilized human egg cell © Science Photo Library

As the pace of technology moves at ever greater speeds, how vulnerable are we when making split second decisions? Kevin Fong flies with the Helicopter Emergency Medical Service, making split-second, life-or-death decisions. He examines how we can come to terms with the growing challenge of quick and accurate front line decision making.

Picture: Presenter, Kevin Fong in air ambulance, Credit: BBC

Ever wished you could miss an entire cold dark winter like bears or dormice? Kevin Fong explores the possibilities than humans could hibernate. This ability could help us recover from serious injury or make long space flights pass in a flash.

The first report on human hibernation in a medical journal was in the BMJ in 1900. It was an account of Russian peasants who, the author claimed, were able to hibernate. Existing in a state approaching "chronic famine", residents of the north-eastern Pskov region would retreat indoors at the first sign of snow, and there gather around the stove and fall into a deep slumber they called "lotska". No-one has ever found these peasants but there is serious research into putting humans into suspended animation, for long distance space travel or for allowing the body to recover from major injury.

The greatest clues into how to pull off hibernation comes from the American Black Bear. Dr Kevin Fong, an expert in trauma medicine, talks to Dr Brian Barnes, Director of the Institute of Arctic Biology at the University of Alaska. He's done the most extensive study of black bears and observed how they slow down their metabolism. Fat-tailed lemurs are the only primates to hibernate. Duke University's Lemur Research Centre has discovered that they breathe just once every 20 minutes at their deepest torpor. These lemurs live longer than other animals of similar size. Could we find a way to use this trick of suspended animation? We could slow down out physiology ,cool down our bodies and hibernate during long space journeys. NASA too is working on how humans can survive trips to other solar systems.

Kevin Fong goes to the lab of Professor Robert Henning at the University Medical Centre in Groningen where he's worked out how animals protect their organs when they slow their body metabolism , enter a state of torpor and then return to normal physiology. Rob Henning wants to apply this to humans, on earth and in space. Already doctors use cooling in patients who have serious head injuries. Could this technique be applied further to allow us to fight disease and buy time for surgeons in the hospital trauma unit?

Producer: Adrian Washbourne

Image credit: Spaceworks

Internet shopping continues to rise worldwide. That means a lot more delivery vans on the streets of our towns and cities. Those vans and trucks, often powered by dirty diesel engines, are contributing to air pollution problems that can cause significant increases in premature death and great discomfort for people suffering from heart and lung conditions.

As part of the BBC’s So I Can Breathe season Tom Heap sets out to find innovative solutions. Could drones or robots be the answer? Could we cut out the middle man and use 3D printers to create everything we want at home? Perhaps it is simply a matter of converting all those vans to electric or gas power or even carrying out the majority of home deliveries by bike.

With the promise of ever-quicker delivery times the search for a solution becomes ever more urgent if we are to prevent our consumer addiction becoming an air pollution crisis on every doorstep.

(Photo: Tom Heap. Credit: Martin Poyntz-Roberts)